Summit Clinical Trials for Ivonescimab (SMT112)

Ivonescimab: Most Advanced PD-1/VEGF Bispecific Antibody in the U.S. & EU.* Brings two validated mechanisms in oncology1-3 into ONE novel tetravalent molecule.

Phase 3 Study: NCT063960654

A Randomized, Double-blind, Multi-center, Phase III Clinical Study of AK112 or Placebo Combined With Pemetrexed and Carboplatin in Patients With EGFR-mutant Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer Who Have Progressed on or Following Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI) Treatment. Learn more.

HARMONi Fact Sheet

Phase 3 Study: NCT058996085

A randomized, double-blinded, multiregional Phase 3 study of ivonescimab combined with chemotherapy versus pembrolizumab combined with chemotherapy for the first-line treatment of metastatic non-small cell lung cancer.

Planned

Phase 3 Study in 1L PD-L1 High, Metastatic Non-small Cell Lung Cancer (NSCLC)
(NCT not yet assigned)  

For additional information on the HARMONi, HARMONi-3 or HARMONi-7 clinical trials, please contact medinfo@smmttx.com

Ivonescimab Mechanism of Action

For More Information on Ivonescimab click here

Ivonescimab is an investigational therapy that is not approved by any regulatory authority other than China’s National Medical Products Administration (NMPA).

References

  1. Manegold C, et al. J Thorac Oncol 2017;12(2):194-207.
  2. Pardoll, D. Nat Rev Cancer 2012;12(4):252-64.
  3. Tamura R, et al. Med Oncol 2020;37(1):2.
  4. Phase III Study of AK112 for NSCLC Patients. ClinicalTrials.gov identifier: NCT06396065.
    https://clinicaltrials.gov/study/NCT06396065. (Accessed 2024, May 14).
  5. Clinical Study of Ivonescimab for First-line Treatment of Metastatic Squamous NSCLC Patients.
    ClinicalTrials.gov identifier: NCT05899608. https://clinicaltrials.gov/study/NCT05899608. (Accessed 2024, May 14).

*There are no known PD-1-based bispecific antibodies approved by the U.S. Food and Drug Administration (“FDA”) or the European Medicines Agency (“EMA”).